Abstract: Twelve very strong lead-resistant strains of microbes were isolated from soil through adding a definite concentration of Pb (300mg/kg) in the medium.No.1 to No.5 strains were bacteria,No.6 to No.9 were actinomyces and No.10 to No.12 were fungi.Through observation on their microcosmic orphology,antagonizing test and simulated Pb-removing experiments of lead-contaminated liquid and soil by these bacterium,it is found that twelve resistant strains of microbe are effective in lead-reducing.The lead-reducing effects of No.3,No.4,No.6,No.7,No.8 and No.10 are higher in liquid test,the reducing rate can reach more than 70%;the effects of No.3 and No.7 are higher in soil,the reducing rate can reach 63.8% and 66%,respectively.